Zofenopril
From Wikipedia, the free encyclopedia
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Zofenopril
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| Systematic (IUPAC) name | |
| (2S,4S)-1-[(2S)-3-(Benzoylsulfanyl)-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid | |
| Identifiers | |
| CAS number | |
| ATC code | C09 |
| PubChem | |
| Chemical data | |
| Formula | C22H23NO4S2 |
| Mol. mass | 429.552 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
Zofenopril (also known as Zofenoprilum [Latin]) is an angiotensin converting enzyme (ACE) inhibitor with cardioprotective properties indicated for the treatment of hypertension.[1]
In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with less adverse effects.[2][3]
[edit] References
- ^ Ambrosioni E (2007). "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". Am J Cardiovasc Drugs 7 (1): 17–24. PMID 17355163.
- ^ Nilsson P (October 2007). "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Press Suppl 2: 25–30. PMID 18046976.
- ^ Mallion JM (October 2007). "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Press Suppl 2: 13–8. PMID 18046974.
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