ZNF274
From Wikipedia, the free encyclopedia
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Zinc finger protein 274
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| Identifiers | ||||||||||||||
| Symbol(s) | ZNF274; DKFZp686K08243; FLJ37843; HFB101; ZF2; ZKSCAN19 | |||||||||||||
| External IDs | OMIM: 605467 MGI: 1890378 HomoloGene: 11298 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 10782 | 65020 | ||||||||||||
| Ensembl | ENSG00000171606 | ENSMUSG00000058638 | ||||||||||||
| Uniprot | Q96GC6 | n/a | ||||||||||||
| Refseq | NM_016324 (mRNA) NP_057408 (protein) |
NM_022981 (mRNA) NP_075357 (protein) |
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| Location | Chr 19: 63.39 - 63.42 Mb | Chr 7: 11.74 - 11.75 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Zinc finger protein 274, also known as ZNF274, is a human gene.[1]
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals.[1]
[edit] References
[edit] Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
- Petroni D, Bartolini E, Chiaramonte R, et al. (1999). "Computer sequence analysis of human highly conserved zinc finger modules.". DNA Seq. 9 (3): 163-9. PMID 10520746.
- Casademunt E, Carter BD, Benzel I, et al. (2000). "The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death.". EMBO J. 18 (21): 6050-61. doi:. PMID 10545116.
- Yano K, Ueki N, Oda T, et al. (2000). "Identification and characterization of human ZNF274 cDNA, which encodes a novel kruppel-type zinc-finger protein having nucleolar targeting ability.". Genomics 65 (1): 75-80. doi:. PMID 10777669.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724-9. doi:. PMID 15498874.
- Sripathy SP, Stevens J, Schultz DC (2007). "The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression.". Mol. Cell. Biol. 26 (22): 8623-38. doi:. PMID 16954381.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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