ZHX1

From Wikipedia, the free encyclopedia

Zinc fingers and homeoboxes 1
PDB rendering based on 2ecb.
Available structures: 2ecb, 2ghf
Identifiers
Symbol(s) ZHX1;
External IDs OMIM: 604764 MGI109271 HomoloGene5225
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 11244 22770
Ensembl ENSG00000165156 ENSMUSG00000022361
Uniprot Q9UKY1 Q5DTL2
Refseq NM_001017926 (mRNA)
NP_001017926 (protein)
NM_001042438 (mRNA)
NP_001035903 (protein)
Location Chr 8: 124.33 - 124.36 Mb Chr 15: 57.88 - 57.91 Mb
Pubmed search [1] [2]

Zinc fingers and homeoboxes 1, also known as ZHX1, is a human gene.[1]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.[1]

[edit] References

[edit] Further reading

  • Yamada K, Printz RL, Osawa H, Granner DK (1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y.". Biochem. Biophys. Res. Commun. 261 (3): 614-21. doi:10.1006/bbrc.1999.1087. PMID 10441475. 
  • Yamada K, Osawa H, Granner DK (1999). "Identification of proteins that interact with NF-YA.". FEBS Lett. 460 (1): 41-5. PMID 10571058. 
  • Hirano S, Yamada K, Kawata H, et al. (2002). "Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer.". Gene 290 (1-2): 107-14. PMID 12062805. 
  • Yamada K, Kawata H, Matsuura K, et al. (2002). "Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1).". Biochem. Biophys. Res. Commun. 297 (2): 368-74. PMID 12237128. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.". Biochem. J. 373 (Pt 1): 167-78. doi:10.1042/BJ20021866. PMID 12659632. 
  • Kawata H, Yamada K, Shou Z, et al. (2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor.". Biochem. J. 373 (Pt 3): 747-57. doi:10.1042/BJ20030171. PMID 12741956. 
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853-65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.". J. Biol. Chem. 281 (51): 39681-92. doi:10.1074/jbc.M606664200. PMID 17056598. 
  • Kim SH, Park J, Choi MC, et al. (2007). "Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression.". Biochem. Biophys. Res. Commun. 355 (2): 318-23. doi:10.1016/j.bbrc.2007.01.187. PMID 17303076.