ZRSR2

From Wikipedia, the free encyclopedia


Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
Identifiers
Symbol(s) ZRSR2; MGC142014; MGC142040; U2AF1-RS2; U2AF1L2; U2AF1RS2; URP
External IDs OMIM: 300028 MGI103287 HomoloGene21061
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 8233 22184
Ensembl ENSG00000169249 ENSMUSG00000031370
Uniprot Q15696 Q62377
Refseq NM_005089 (mRNA)
NP_005080 (protein)
NM_009453 (mRNA)
NP_033479 (protein)
Location Chr X: 15.72 - 15.75 Mb Chr X: 159.28 - 159.3 Mb
Pubmed search [1] [2]

Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2, also known as ZRSR2, is a human gene.[1]

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly.[1]

[edit] References

[edit] Further reading

  • Kitagawa K, Wang X, Hatada I, et al. (1996). "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.". Genomics 30 (2): 257-63. PMID 8586425. 
  • Tronchère H, Wang J, Fu XD (1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.". Nature 388 (6640): 397-400. doi:10.1038/41137. PMID 9237760. 
  • Brunner B, Todt T, Lenzner S, et al. (1999). "Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1.". Genome Res. 9 (5): 437-48. PMID 10330123. 
  • Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456-64. PMID 10508479. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.". RNA 10 (6): 929-41. PMID 15146077. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.