ZNRD1

From Wikipedia, the free encyclopedia


Zinc ribbon domain containing 1
Identifiers
Symbol(s) ZNRD1; HTEX-6; MGC13376; Rpa12; hZR14; tctex-6
External IDs OMIM: 607525 MGI1913386 HomoloGene40960
Orthologs
Human Mouse
Entrez 30834 66136
Ensembl ENSG00000066379 ENSMUSG00000036315
Uniprot Q9P1U0 Q791N7
Refseq NM_014596 (mRNA)
NP_055411 (protein)
NM_023162 (mRNA)
NP_075651 (protein)
Location Chr 6: 30.14 - 30.14 Mb Chr 17: 36.56 - 36.57 Mb
Pubmed search [1] [2]

Zinc ribbon domain containing 1, also known as ZNRD1, is a human gene.[1]

This gene encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.[1]

[edit] References

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Lepourcelet M, Andrieux N, Giffon T, et al. (1997). "Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence.". Genomics 37 (3): 316–26. PMID 8938444. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Fan W, Wang Z, Kyzysztof F, et al. (2000). "A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region.". Genomics 63 (1): 139–41. doi:10.1006/geno.1999.6040. PMID 10662553. 
  • Coriton O, Lepourcelet M, Hampe A, et al. (2001). "Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes.". Mamm. Genome 11 (12): 1127–31. PMID 11130983. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Shi Y, Zhang Y, Zhao Y, et al. (2004). "Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein.". Cancer Biol. Ther. 3 (4): 377–81. PMID 14726695. 
  • Hong L, Zhang Y, Liu N, et al. (2004). "Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene.". Biochem. Biophys. Res. Commun. 321 (3): 611–6. doi:10.1016/j.bbrc.2004.07.007. PMID 15358150. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Hong L, Han Y, Shi R, et al. (2005). "ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase.". Cancer Biol. Ther. 4 (1): 60–4. PMID 15662122. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Hong L, Zhao Y, Han Y, et al. (2007). "Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells.". Carcinogenesis 28 (8): 1622–8. doi:10.1093/carcin/bgm064. PMID 17389617. 
  • Hong L, Wang J, Zhao Y, et al. (2007). "DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1.". Cancer Invest. 25 (8): 699–705. doi:10.1080/07357900701566304. PMID 18058465.