ZNF160

From Wikipedia, the free encyclopedia


Zinc finger protein 160
Identifiers
Symbol(s) ZNF160; F11; DKFZp686B16128; FLJ00032; HKr18; HZF5; KIAA1611; KR18
External IDs OMIM: 600398 MGI99173 HomoloGene85229
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 90338 22688
Ensembl ENSG00000170949 ENSMUSG00000063108
Uniprot Q9HCG1 n/a
Refseq NM_033288 (mRNA)
NP_150630 (protein)
XM_134736 (mRNA)
XP_134736 (protein)
Location Chr 19: 58.26 - 58.3 Mb Chr 9: 20.19 - 20.21 Mb
Pubmed search [1] [2]

Zinc finger protein 160, also known as ZNF160, is a human gene.[1]

The protein encoded by this gene is a Kruppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Two alternative transcripts encoding the same isoform have been described.[1]

[edit] References

[edit] Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mark C, Looman C, Abrink M, Hellman L (2001). "Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19.". DNA Cell Biol. 20 (5): 275-86. doi:10.1089/104454901750232472. PMID 11410164. 
  • Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen.". DNA Res. 7 (6): 357-66. PMID 11214971. 
  • Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273-81. PMID 10997877. 
  • Abrink M, Aveskogh M, Hellman L (1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.". DNA Cell Biol. 14 (2): 125-36. PMID 7865130. 
  • Halford S, Mattei MG, Daw S, Scambler PJ (1995). "A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4.". Genomics 25 (1): 322-3. PMID 7774943.