Talk:Ziprasidone

From Wikipedia, the free encyclopedia

Ziprasidone is part of WikiProject Pharmacology, a project to improve all Pharmacology-related articles. If you would like to help improve this and other pharmacology articles, please join the project. All interested editors are welcome.
B This article has been rated as B-Class on the quality scale.
Low This article has been rated as Low-importance for this Project's importance scale.


Contents

[edit] adverse effects

please reference the heart attack statement that says it has been known to cause heart attacks —Preceding unsigned comment added by 71.103.107.40 (talk) 01:18, 15 September 2007 (UTC)


" (Geodon may alter the QT interval of heart I think I heard)~~johnericfranklin@rock.com~~ "About 1 in 10-20 (approximately) patient titrated up to high doses of Geodon (360mg a day) will show a significant improvment in cognition."



Geodon also lowers the seizure threshold, which is its big difference from Risperdal. That's definitely important. —Preceding unsigned comment added by 74.69.98.18 (talk) 04:48, 29 November 2007 (UTC)

[edit] Request for expansion

This is a "black box drug" in the USA because of prolonged QT syndrome, the only atypical antipsychotic to be labeled as such as far as I know. The main reason I'm asking this is because people need to be more aware- my doctor only mentioned it in passing, and I got the impression it was a very rare reaction. Suffice it to say I developed acquired Long QT Syndrome which went undetected for a long while until one day it apparently degenerated into Torsades de pointes while in the hospital for something unrelated. I nearly died and was shocked that it was a result of my Geodon. In short, while I'm no writer, I would highly appreciate it if someone wrote about the black box warning about cardiac arrythmias from Geodon. http://www.fda.gov/medWatch/safety/2002/geodon.htm - Source of information from FDA. 76.185.121.215 02:57, 1 August 2007 (UTC)

[edit] Talk: Ziprasidone 1st Section

I would like to see a reference to support this statement in the article. The effects of the atypical antipsychotics on cognition are widely debated, and IMO, are likely of minimal clinical significance. Secondly, no atypical has been conclusively shown to be more effective with regards to restoring or preserving cognitive functioning than any other atypical. While individual studies may suggest benefit of one agent over another, the data when viewed collectively is not clear cut. I aware of no conclusive evidence to make the statement that ziprasidone is better than olanzapine or risperidone in regards to preservation or restoration of cognitive functioning. The head to head data either does not exist or is not robust. Absent a reference supporting the statements made in the pharmacology section regarding cognition effects with ziprasidone, I am going to delete this information.

If anyone is aware of conclusive data supporting this statement I would be interested in seeing it.

Statement sounds largely speculative. A literature reference should definitely be cited, but the part about, "1 in 10-20" sounds a bit fishy to me. There's a big difference in the difference between "1 in 10" and "1 in 20" (either 5% or 10%). Dr. Cash 03:55, 21 August 2005 (UTC)

I have a problem with this sentence in the article: ("The medication can cause any conceivable side effect") Any conceivable side-effec??????? Including death, heart-attack, stroke, coma, itching, scratching and a runny nose????? This is non-sense I guess geodon causes many side-effects but hardly every side effect conceivable. Please remove or rewrite this sentence! Jeroen.


[edit] sickness

I have been taken Geodon since January 19,2007 but stoped on the 22nd of January 2007 because of Nausea and vomiting (threwing up) and a case of the Stomach Virus. My Neurologist told me to take Geodon but did not work out. Wikipedia should start an article on Stomach Virus. From Mrsanitazier 23, January 2007 7:08 PM Eastern Standard Time.