Talk:Zoledronate
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[edit] Kidney disease?
The article says:
Zoledronate is rapidly processed via the kidneys; consequently its administration is not recommended for patients with reduced renal function or kidney disease.
I'm sure this is true of almost any drugs, but some casual clicking around in Medline and elsewhere didn't turn up anything like this. For example, this article says
tell your doctor if you are being treated wtih radiation therapy and if you have or have ever had heart failure (condition in which the heart cannot pump enough blood to other parts of the body); anemia (condition in which red blood cells cannot bring enought oxygen to the other parts of the body); any condition that stops your blood from clotting normally; problems with your mouth, teeth, or gums; an infection, especially in your mouth; asthma, especially if it is made worse by aspirin; or kidney or liver disease
I'd think almost any drug might stress the kidneys and I'd think any patient ought to tell their doctor about kidney or liver disease before starting any significant course of drug treatment. The article seems to imply that zoledronate has a special risk, requiring a special caution. I have no reason to doubt this, but I'd like to see a citation. Dpbsmith (talk) 15:55, 1 April 2008 (UTC)
- Renal toxicity is an issue for all bisphosphonates as the non bone-binding drug is rapidly cleared by the kidneys. Thus they all have the standard warning regarding patients with compromised kidney function. Here is a citation for a ZA specific report that shows renal impairment in 23.8% of patients.
Oh WK, Proctor K, Nakabayashi M, Evan C, Tormey LK, Daskivich T, AntrĂ s L, Smith M, Neary MP, Duh MS. The risk of renal impairment in hormone-refractory prostate cancer patients with bone metastases treated with zoledronic acid. Cancer. 2007 Mar 15;109(6):1090-6. PMID: 17311345 Dr Aaron (talk) 13:30, 2 April 2008 (UTC)

