Zileuton

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Zileuton
Systematic (IUPAC) name
1-(1-benzothiophen-2-ylethyl)-1-hydroxy-urea
Identifiers
CAS number 111406-87-2
ATC code  ?
PubChem 60490
DrugBank APRD00265
Chemical data
Formula C11H12N2O2S 
Mol. mass 236.291 g/mol
Pharmacokinetic data
Bioavailability Not yet established
Protein binding 93%
Metabolism Hepatic (CYP1A2, CYP2C9 and CYP3A4-mediated)
Half life 2.5 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status

-only(US)

Routes Oral

Zileuton (INN) is an asthma drug. It blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.

Zileuton is marketed by Critical Therapeutics under the brand name Zyflo. As of February 20th, 2008, Zyflo tablets are to be discontinued, although Zyflo CR is still available [1]

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