Talk:Zopiclone
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Zopiclone is identical to eszopiclone, aside from the fact that it has an extra 50% inactive "filler" -- namely, the inactive isomer of the drug. Therefore, most of its properties are idential to eszopiclone, so I have copied many of the properties from that entry. Bushing 15:35, 3 December 2005 (UTC).
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[edit] Blurred vision?
I've asked a pharmacist to look up vision related side effects for Zopiclone, and he has indicated to me the only one that's on that big heavy text is ambiyopia - dimmed vision. Ambiyopia is can be specific to dimmed vision at night, and may be caused by toxicity, or by (in this case) prescription drugs. There's no word that blurred vision is in that list. 142.58.101.27 02:29, 28 March 2006 (UTC).
Blurred vision could be due to the dehydration and the associated swelling, it's something that can affect your eyesight as well. --Snowgrouse 19:24, 20 January 2007 (UTC)
Currently on this funky tablet before bed, feeling abit dizzy though and wikipedia edited has proved difficult. JHJPDJKDKHI! 07:08, 2 April 2006 (UTC).
[edit] Specific claim in need of a specific citation
A statement as specific as this really needs to be verified directly with a specific reference: "The risk of dependency on zopiclone when used for less than 4 weeks or used occasionally is very low." If a direct citation for this can't be found, it should be removed from the article. - Pacula 19:03, 23 September 2007 (UTC)
- How about this for a source? It suggests that Zopiclone has a low addiction level if taken in therapeutic doses for a few weeks, and the statement is supported by citing the following two studies:
1. Wadworth AN, McTavish D. Zopiclone: a review of its pharmacological properties and therapeutic efficacy as a hypnotic. Drugs & Aging 1993;3:441-59.
2. Lader M. Zopiclone: is there any dependence and abuse potential? J Neurol 1997;244:S18-S22. Albert Wincentz (talk) 17:46, 9 January 2008 (UTC)
- not a great cite, but the patient information leaflet for zopiclone in the UK says "If you are taking any medicines belonging to the hypnotic group there is a possibility that you may become dependant on them However, with Zimovane this possibility is small." I'm not sure what rules guide what info they can put into leaflets. :-/ Dan Beale-Cocks 21:18, 4 March 2008 (UTC)
[edit] Lunesta in U.S. only
The article states that eszopiclone is sold in North America whereas zopiclone is available in Europe. In fact, zopiclone is sold in Canada as well, where eszopiclone is unavailable. Puck35 (talk) 03:51, 28 January 2008 (UTC)
[edit] overdose
Overdose of zopiclone may present with excessive sedation, depressed respiratory function which may progress to coma and possibly death. - is there any cite for the coma or death part of this? I'm not aware of anyone ever anywhere dying from zopiclone overdose. Zopiclone is used quite a lot in UK mental health trusts because it's "so safe". Dan Beale-Cocks 21:23, 4 March 2008 (UTC)
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- I've found a few cites showing zopiclone used in overdose - 78 year old 350mg zopiclone only, contributory, not cause of death. I was going to remove the death bit, but I won't now. Dan Beale-Cocks 10:53, 11 March 2008 (UTC)
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- Indeed, there are plenty of source showing zopiclone is the primary cause of overdose death. :-( Dan Beale-Cocks 21:05, 29 March 2008 (UTC)
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[edit] Cancer
This study - Incidence of Cancer in Individuals Receiving Chronic Zopiclone or Eszopiclone Requires Prospective Study does say that, uh, the incidence of cancer in people getting zopiclone long-term needs to be studied, but it doesn't say that they found "an increase in cancer rates" in people with HIV/AIDS who had been given zopiclone. It's hard to see how relevant the animal studies are:
[. . .]and carcinomas in males were seen, at the highest dose of 100 mg/kg/d. While this is considerably above a typical human daily dose, the mechanism for this increase in mammary tumors is unknown. The thyroid tumors are thought to increase levels of thyroid stimulating hormone via a mechanism not thought to be relevant to humans [. . .] though once again, the relevance to humans of these data are questioned.
Since the study is uncontrolled - no double blinds or control groups etc - it's not suitable for this article to say "zopiclone causes cancer in immuno-suppressed patients". Dan Beale-Cocks 21:11, 29 March 2008 (UTC)
Hi, I printed off the article and took it to work and showed it to a physician and they tended to agree with you that the study did not conclusively state whether zopiclone caused cancer or not and only raised concerns of possible cancer warranting further study etc. I am happy with your rewording of my edit by yourself. Thank you for bringing my misinterpretation of the article to my attention.--Stilldoggy (talk) 01:05, 2 April 2008 (UTC)

